NAD+ metabolism and its roles in cellular processes during aging
Covarrubias AJ, Perrone R, Grozio A, et al.
Key finding
Tissue NAD+ decline is a shared mechanism across the hallmarks of aging.
Summary
The canonical recent review of NAD+ biology and aging — covers biosynthesis, degradation, sirtuin/PARP/CD38 signaling, and the translation gap from rodent models to human therapy.
Access the full paper
Related research
Nature · 2000
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
Sir2 deacetylase activity consumes NAD+, establishing a direct biochemical link between cellular NAD+ levels and gene silencing.
Science · 2000
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae
Calorie-restriction-induced lifespan extension requires intact NAD+ biosynthesis and Sir2, linking nutrient sensing to sirtuin-mediated longevity.
PLOS One · 2012
Age-associated changes in oxidative stress and NAD+ metabolism in human tissue
Skin NAD+ declines with age in humans, correlating with rising oxidative stress and poly-ADP-ribose accumulation — direct human evidence of the age-related NAD+ deficit.