NAD+ metabolism and its roles in cellular processes during aging
Covarrubias AJ, Perrone R, Grozio A, et al.
Key finding
Tissue NAD+ decline is a shared mechanism across the hallmarks of aging. Source: Covarrubias AJ, Perrone R, Grozio A, et al. Nature Reviews Molecular Cell Biology, 2021.
Summary
The canonical recent review of NAD+ biology and aging — covers biosynthesis, degradation, sirtuin/PARP/CD38 signaling, and the translation gap from rodent models to human therapy.
Frequently asked questions
- What did Covarrubias et al. (2021) find about NAD+?
- Tissue NAD+ decline is a shared mechanism across the hallmarks of aging. Source: Covarrubias AJ, Perrone R, Grozio A, et al. "NAD+ metabolism and its roles in cellular processes during aging." Nature Reviews Molecular Cell Biology, 2021.
- What kind of study is Covarrubias 2021?
- It is a review study on NAD+ published in Nature Reviews Molecular Cell Biology in 2021. The canonical recent review of NAD+ biology and aging — covers biosynthesis, degradation, sirtuin/PARP/CD38 signaling, and the translation gap from rodent models to human therapy.
- Where can I read the full Covarrubias 2021 paper?
- The primary source is available on PubMed (PMID 33353981) and via DOI 10.1038/s41580-020-00313-x.
Access the full paper
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