NAD+ Precursors
The five molecules that raise cellular NAD+ when administered — their molecular structure, entry points into the salvage or Preiss-Handler pathway, and the human evidence behind each.
Nicotinamide Mononucleotide
NMN
The direct precursor with dedicated intestinal transport
- Molecular Weight
- 334.22 g/mol
- Bioavailability
- 85
- Regulatory
- FDA Review
- Typical Dose
- 250-500 mg/day
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Nicotinamide Riboside
NR
The first orally bioavailable NAD+ precursor to reach market
- Molecular Weight
- 255.25 g/mol
- Bioavailability
- 65
- Regulatory
- FDA GRAS
- Typical Dose
- 300-600 mg/day
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Nicotinamide Adenine Dinucleotide
NAD+
The end-state coenzyme — administered directly in clinical IV
- Molecular Weight
- 663.43 g/mol
- Bioavailability
- 25
- Regulatory
- Clinical Only
- Typical Dose
- 250-1,000 mg IV drip over 2-4 hours
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Nicotinamide
Nam
The cheap, flush-free B3 that most Nam → NAD+ routes lead to
- Molecular Weight
- 122.12 g/mol
- Bioavailability
- 90
- Regulatory
- FDA GRAS
- Typical Dose
- 500-1,000 mg/day for NAD+ elevation
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Niacin
NA
The Preiss-Handler route — the flushing cousin of Nam
- Molecular Weight
- 123.11 g/mol
- Bioavailability
- 80
- Regulatory
- FDA GRAS
- Typical Dose
- 250-1,000 mg/day (ER formulations to blunt flush)
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