Mechanism — pathway

The Salvage Pathway

NAMPT recycles nicotinamide back into NAD+.

The dominant route of NAD+ regeneration in mammals. NAMPT converts nicotinamide (Nam) to nicotinamide mononucleotide (NMN), which NMNAT1-3 then adenylates into NAD+. NAMPT expression declines with age and is rate-limiting for intracellular NAD+ levels.

Precursors that interact with The Salvage Pathway

NMN

Nicotinamide Mononucleotide

The direct precursor with dedicated intestinal transport

Nicotinamide Riboside

The first orally bioavailable NAD+ precursor to reach market

Nam

Nicotinamide

The cheap, flush-free B3 that most Nam → NAD+ routes lead to

Related benefits

Safety & Drug Interactions

Methylation, sirtuin inhibition, and co-therapies

Immune Function

CD38, T-cell metabolism, and immunosenescence

Sleep & Circadian Rhythm

BMAL1/CLOCK-NAMPT loop and sirtuin-driven circadian control

Inflammation & Inflammaging

CD38, SIRT1/SIRT6, and chronic low-grade inflammation

Liver & Hepatic Metabolism

NAFLD/MASLD, alcohol metabolism, and SIRT1 in the liver