NAD+ Benefits
An evidence-graded review of what NAD+ supplementation does — and doesn’t yet do — across longevity, cognition, metabolism, and other outcomes. Strength-of-evidence ratings reflect human trial quality.
Longevity & Healthy Aging
Cellular senescence, lifespan, and healthspan markers
Cognitive Function
Neuroprotection and memory in aging brains
Metabolic Health
Insulin sensitivity, lipids, and body composition
DNA Repair & Genomic Stability
PARP activation and base excision repair
Muscle Performance
Mitochondrial biogenesis and endurance
Cardiovascular Health
Endothelial function and arterial stiffness
Skin & Dermatology
Chemoprevention and topical applications
Safety & Drug Interactions
Methylation, sirtuin inhibition, and co-therapies
Immune Function
CD38, T-cell metabolism, and immunosenescence
Sleep & Circadian Rhythm
BMAL1/CLOCK-NAMPT loop and sirtuin-driven circadian control
Inflammation & Inflammaging
CD38, SIRT1/SIRT6, and chronic low-grade inflammation
Exercise Performance
PGC-1α-SIRT1 axis and NAD+ kinetics with training
Liver & Hepatic Metabolism
NAFLD/MASLD, alcohol metabolism, and SIRT1 in the liver
Fertility & Reproductive Aging
Oocyte quality, maternal aging, and NAD+ rescue