Benefit
DNA Repair & Genomic Stability
PARP activation and base excision repair.
Strong human evidence
PARP-1 uses NAD+ as its sole substrate to signal DNA damage. Depleted NAD+ pools are associated with reduced repair capacity, genomic instability, and cellular senescence. This is the most mechanistically concrete role of NAD+.
Key studies
Science · 2017 · PMID 28360259
A conserved NAD+ binding pocket that regulates protein-protein interactions during aging
Li J, et al.
Editorial note
NADFaq grades evidence on a 4-tier scale based on human trial quality, sample size, reproducibility, and mechanistic plausibility. This is a conservative framework — many published benefits of NAD+ precursors rest on preclinical (rodent or cell) work that has not yet translated to humans.
How we grade evidence