NAD+ Mechanisms

The pathways and enzymes behind NAD+ biology — how it’s synthesized, recycled, consumed, and compartmentalized across the cell.

The Salvage Pathway

NAMPT recycles nicotinamide back into NAD+

Niacin enters NAD+ biosynthesis without salvage

Tryptophan → quinolinic acid → NAD+

NAD+-dependent deacylases governing cellular stress

The largest NAD+ consumer under DNA damage

The NAD+ hydrolase that explains age-related decline

Where NAD+ drives electron transport and ATP synthesis

NAD+-fueled base excision and strand-break repair

The rate-limiting enzyme of the salvage pathway

The kinases that phosphorylate NR into NMN