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Benefit

Fertility & Reproductive Aging

Oocyte quality, maternal aging, and NAD+ rescue.

Preclinical only

Oocyte NAD+ declines with maternal age, and NMN supplementation in aged female mice restored oocyte quality, spindle assembly, and live-birth rates in Sinclair-group work. Mechanisms implicate SIRT2-dependent deacetylation and mitochondrial function during meiotic maturation. Human evidence is preclinical-adjacent: no adequately powered controlled trials of NAD+ precursors on oocyte quality or clinical pregnancy rates have been published.

Key studies

  1. Cell Reports · 2020 · PMID 32049001

    NAD+ repletion rescues female fertility during reproductive aging

    Bertoldo MJ, et al.

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  2. Science · 2016 · PMID 27127236

    NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

    Zhang H, et al.

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  3. Development · 2015 · PMID 25617434

    Mitochondrial dysfunction in oocytes of obese mothers: transmission to offspring and reversal by pharmacological endoplasmic reticulum stress inhibitors

    Wu LL, et al.

Editorial note

NADFaq grades evidence on a 4-tier scale based on human trial quality, sample size, reproducibility, and mechanistic plausibility. This is a conservative framework — many published benefits of NAD+ precursors rest on preclinical (rodent or cell) work that has not yet translated to humans.

How we grade evidence