Benefit
Cognitive Function
Neuroprotection and memory in aging brains.
Emerging human evidence
NAD+ availability in neurons regulates SIRT1/3 activity, mitochondrial bioenergetics, and neurovascular coupling. The strongest human data sits in small-cohort trials of mild cognitive impairment and subjective cognitive fatigue.
Key studies
Cell Metabolism · 2019 · PMID 31577933
NAD+ in brain aging and neurodegenerative disorders
Lautrup S, et al.
Editorial note
NADFaq grades evidence on a 4-tier scale based on human trial quality, sample size, reproducibility, and mechanistic plausibility. This is a conservative framework — many published benefits of NAD+ precursors rest on preclinical (rodent or cell) work that has not yet translated to humans.
How we grade evidence