Benefit
Metabolic Health
Insulin sensitivity, lipids, and body composition.
Moderate human evidence
NMN's 2021 Yoshino trial demonstrated improved muscle insulin sensitivity in postmenopausal women — the cleanest human mechanistic result in the field. Broader metabolic effects remain under active investigation.
Key studies
Science · 2021 · PMID 33888596
Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women
Yoshino M, et al.
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Editorial note
NADFaq grades evidence on a 4-tier scale based on human trial quality, sample size, reproducibility, and mechanistic plausibility. This is a conservative framework — many published benefits of NAD+ precursors rest on preclinical (rodent or cell) work that has not yet translated to humans.
How we grade evidence