Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women
Yoshino M, Yoshino J, Kayser BD, et al.
Key finding
NMN improved skeletal muscle insulin sensitivity and gene expression in postmenopausal women. Source: Yoshino M, Yoshino J, Kayser BD, et al. Science, 2021.
Summary
Randomized, placebo-controlled 10-week trial of 250 mg/day NMN in postmenopausal women with prediabetes. The first human trial to show a concrete mechanistic metabolic benefit.
For background on the compound studied here, see our NMN precursor reference.
Frequently asked questions
- What did Yoshino et al. (2021) find about NMN?
- NMN improved skeletal muscle insulin sensitivity and gene expression in postmenopausal women. Source: Yoshino M, Yoshino J, Kayser BD, et al. "Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women." Science, 2021.
- What kind of study is Yoshino 2021?
- It is a clinical trial on NMN published in Science in 2021. Randomized, placebo-controlled 10-week trial of 250 mg/day NMN in postmenopausal women with prediabetes. The first human trial to show a concrete mechanistic metabolic benefit.
- Where can I read the full Yoshino 2021 paper?
- The primary source is available on PubMed (PMID 33888596) and via DOI 10.1126/science.abe9985.
Access the full paper
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