Slc12a8 is a nicotinamide mononucleotide transporter
Grozio A, Mills KF, Yoshino J, et al.
Key finding
Oral NMN reaches tissues intact via a dedicated intestinal transporter.
Summary
Identified Slc12a8 as a dedicated NMN transporter in the small intestine. Established a pharmacological basis for oral NMN bioavailability distinct from the Nam-salvage route.
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