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NADFaq.com

Benefit

Cardiovascular Health

Endothelial function and arterial stiffness.

Emerging human evidence

Small human trials report improvements in endothelial function and arterial stiffness with NR supplementation. Mechanistic basis: sirtuin-mediated eNOS deacetylation and mitochondrial bioenergetics in vascular smooth muscle.

Key studies

  1. Nature Communications · 2018 · PMID 29599478

    Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults

    Martens CR, et al.

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Editorial note

NADFaq grades evidence on a 4-tier scale based on human trial quality, sample size, reproducibility, and mechanistic plausibility. This is a conservative framework — many published benefits of NAD+ precursors rest on preclinical (rodent or cell) work that has not yet translated to humans.

How we grade evidence