Benefit
Longevity & Healthy Aging
Cellular senescence, lifespan, and healthspan markers.
Moderate human evidence
The link between NAD+ decline and the hallmarks of aging — mitochondrial dysfunction, genomic instability, telomere attrition, and altered nutrient sensing. Covers preclinical lifespan data in mice, human biomarker studies, and the translation gap between model organisms and clinical trials.
Key studies
Nature Reviews Molecular Cell Biology · 2021 · PMID 33353981
NAD+ declines during aging and is linked to age-related diseases
Covarrubias AJ, et al.
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Editorial note
NADFaq grades evidence on a 4-tier scale based on human trial quality, sample size, reproducibility, and mechanistic plausibility. This is a conservative framework — many published benefits of NAD+ precursors rest on preclinical (rodent or cell) work that has not yet translated to humans.
How we grade evidence