Niacin cures systemic NAD+ deficiency and improves muscle performance in adult-onset mitochondrial myopathy
Pirinen E, Auranen M, Khan NA, et al.
Key finding
Niacin restored NAD+ and improved muscle function in mitochondrial myopathy patients. Source: Pirinen E, Auranen M, Khan NA, et al. Cell Metabolism, 2020.
Summary
10-month niacin titration in patients with mitochondrial myopathy restored muscle NAD+ and improved strength and muscle mass — the clearest clinical efficacy result for any NAD+ precursor.
For background on the compound studied here, see our NIACIN precursor reference.
Frequently asked questions
- What did Pirinen et al. (2020) find about NIACIN?
- Niacin restored NAD+ and improved muscle function in mitochondrial myopathy patients. Source: Pirinen E, Auranen M, Khan NA, et al. "Niacin cures systemic NAD+ deficiency and improves muscle performance in adult-onset mitochondrial myopathy." Cell Metabolism, 2020.
- What kind of study is Pirinen 2020?
- It is a clinical trial on NIACIN published in Cell Metabolism in 2020. 10-month niacin titration in patients with mitochondrial myopathy restored muscle NAD+ and improved strength and muscle mass — the clearest clinical efficacy result for any NAD+ precursor.
- Where can I read the full Pirinen 2020 paper?
- The primary source is available on PubMed (PMID 32386567) and via DOI 10.1016/j.cmet.2020.04.008.