Nicotinamide riboside augments the aged human skeletal muscle NAD+ metabolome
Elhassan YS, Kluckova K, Fletcher RS, et al.
Key finding
NR raises tissue NAD+ in aged muscle and shifts mitochondrial transcription. Source: Elhassan YS, Kluckova K, Fletcher RS, et al. Cell Reports, 2019.
Summary
21-day NR supplementation at 1 g/day in aged men raised skeletal muscle NAD+ and shifted mitochondrial gene expression — the first mechanistic human data on tissue-level NAD+ response.
For background on the compound studied here, see our NR precursor reference.
Frequently asked questions
- What did Elhassan et al. (2019) find about NR?
- NR raises tissue NAD+ in aged muscle and shifts mitochondrial transcription. Source: Elhassan YS, Kluckova K, Fletcher RS, et al. "Nicotinamide riboside augments the aged human skeletal muscle NAD+ metabolome." Cell Reports, 2019.
- What kind of study is Elhassan 2019?
- It is a clinical trial on NR published in Cell Reports in 2019. 21-day NR supplementation at 1 g/day in aged men raised skeletal muscle NAD+ and shifted mitochondrial gene expression — the first mechanistic human data on tissue-level NAD+ response.
- Where can I read the full Elhassan 2019 paper?
- The primary source is available on PubMed (PMID 31412242) and via DOI 10.1016/j.celrep.2019.07.043.
Access the full paper
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