Nicotinamide riboside augments the aged human skeletal muscle NAD+ metabolome
Elhassan YS, Kluckova K, Fletcher RS, et al.
Key finding
NR raises tissue NAD+ in aged muscle and shifts mitochondrial transcription.
Summary
21-day NR supplementation at 1 g/day in aged men raised skeletal muscle NAD+ and shifted mitochondrial gene expression — the first mechanistic human data on tissue-level NAD+ response.
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