Blog
Research commentary, precursor updates, and answers to emerging questions. Published under the NADFaq editorial standard — every post is sourced, reviewed, and independent of supplement-industry funding.
What this blog covers. The NADFaq blog tracks the clinical evidence base around nicotinamide adenine dinucleotide — not the marketing narrative. Posts summarize peer-reviewed human trials, pharmacokinetic studies, and mechanistic research across NR, NMN, niacin, nicotinamide, and IV NAD+. Each piece is scoped to a single question and cites PMIDs or DOIs inline so claims can be verified at the source.
What it does not cover. We do not recommend specific brands, run affiliate links, or publish supplement stacks. When the evidence is thin — sublingual pharmacokinetics, long-term safety, oncology interactions — we say so. When a marketing claim outruns the published data, we flag the gap rather than paper over it. Medical decisions belong in a clinical setting. These posts are a reading companion for that conversation, not a substitute for it.
NAD+ Decline With Age: Why Tissue Levels Drop 50% by 70
Tissue NAD+ falls ~50% between age 20 and 70. Rising CD38, declining NAMPT, and PARP activation explain why — and what research says about restoration.
NAD+ Precursor Dosing in Human Trials: What the Evidence Shows
Published NAD+ precursor trials used NR at 100-2000 mg/day, NMN at 250-1200 mg/day, and niacin at 50-2000 mg/day. Here's what the human data actually shows.
NAD+ Precursor Drug Interactions: What Research Shows
Niacin-statin rhabdomyolysis risk is documented; NR/NMN concerns with chemo, anticoagulants, and methyl donors remain theoretical. Ask your clinician first.
IV NAD+ Therapy: What the Evidence Shows
IV NAD+ plasma half-life runs 5-15 minutes, most hydrolyzed before tissue uptake. Sessions cost $300-800. Published clinical evidence remains thin.
How NAD+ Declines with Age: The Mechanistic Picture
Tissue NAD+ falls roughly 50% between age 20 and 70. CD38 upregulation, NAMPT decline, and chronic PARP activation explain most of the depletion — here is how.
What Is NAD+? A Science-First Primer
NAD+ is a coenzyme in every living cell that fuels energy metabolism and regulates sirtuins, PARPs, and CD38. A primer on the biochemistry and why it matters.
NR vs NMN: What Head-to-Head Research Actually Shows
A neutral comparison of NR and NMN — salvage-pathway entry, bioavailability, the Slc12a8 debate, human trials, and side effects. No head-to-head RCT exists yet.
Long-Term NAD+ Precursor Safety: What We Know and Don't
The longest published NR and NMN human trials run 8-12 weeks with no serious adverse events at studied doses. Decade-scale safety data does not yet exist.
Sublingual vs Oral NMN: What the Pharmacokinetic Data Shows
Sublingual vs oral NMN bioavailability: published human PK data is sparse, and '5-10x absorption' marketing claims lack head-to-head human trials.